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YH-306 is a small-molecule focal adhesion kinase (FAK) inhibitor with reported antitumor activity. It suppresses colorectal tumor growth and metastasis by inhibiting FAK signaling, reducing cell migration and invasion, and promoting apoptosis.
faK pathway inhibition reduces tumor cell migration and invasion.
demonstrated antitumor activity in colorectal cancer models.
modulates multiple signaling proteins including c-Src, paxillin, PI3K, and Rac1.
downregulates MMP2 and MMP9 expression to limit metastasis.
supplied as a research reagent, soluble in DMSO for experimental use.
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Also available in 5 mg, 25 mg, 50 mg, 100 mg and bulk. Please contact Fisher for quotes. Biotin-aniline is a probe that reacts strongly to RNA and DNA.Biotin-aniline is highly efficient and is used to capture subcellular transcriptomes in living cells with high spatial specificity. Purity 99.08%
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MS402 is a small-molecule, BD1-selective inhibitor of BET bromodomains used in preclinical research to modulate BET-mediated transcription and Th17-driven inflammatory responses.
Selective BD1 bromodomain inhibition.
Reported Ki values for BET bromodomains, e.g., BRD4(BD1) 77 nM, BRD4(BD2) 718 nM.
Demonstrated activity blocking Th17 cell differentiation and ameliorating colitis in mice.
Purity 98.36% and molecular weight 370.83 g/mol.
Molecular formula C20H19ClN2O3.
Intended for laboratory research use only; not for human use.
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BD-1047 dihydrobromide is a selective functional antagonist of sigma receptors. It attenuates Apomorphine-induced climbing and Phencyclidine-induced head twitches. It is for research use only and not sold to patients.
Selective functional antagonist of sigma receptors.
Attenuates Apomorphine-induced climbing.
Attenuates Phencyclidine-induced head twitches.
Prevents Cutamesine from reducing cell death induced by light exposure in murine photoreceptor-derived 661w cells.
Attenuates Cutamesine from reducing mitochondrial damage and elevated caspase 3/7 activity.
Decreases APO-induced climbing behavior at 10 mg/kg in mice.
Counteracts the antidepressant-like effect induced by co-administration of pramipexole and sertraline.
Reduces the increasing expression of pNR1 and reverses Sig-1 R agonists potentiated NMDA-induced pain behavior and pNR1 immunoreactivity.
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N-Fmoc-1,5-diaminopentane HCl is a Amino Acid reagent (Subcategory: Building Block) sold by WuXi TIDES. Offered in 25 g. Store at 4 °C. SDS available for reference.
Specifications - CAS: 177333-17-4 - MDL: MFCD00832511 - InChIKey: MYVDRDMFYHOZBJ-UHFFFAOYSA-N - Molecular Weight: 360.882 - Molecular Formula: C20H25ClN2O2 - Purity: ≥95% - Container Type: 125 mL HDPE - Pack Size: 25 g - Net Weight: 25 g - Gross Weight: 54.3 g - Commodity Code: 29242970 - Country Of Origin: China - IUPAC: (9H-fluoren-9-yl)methyl (5-aminopentyl)carbamate hydrochloride - SMILES: NCCCCCNC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O.Cl
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VUF 8430 dihydrobromide is a potent, selective histamine H4 receptor agonist supplied as a solid research reagent. It exhibits a Ki of 31.6 nM and an EC50 of 50 nM at the H4 receptor, and is provided in small milligram quantities for pharmacological and biochemical studies. For research use only.